tICA identifies the slowest-relaxing degrees of freedom by maximizing temporal autocorrelation.
Comparison: tICA vs. PCA
| Feature | PCA | tICA |
|---|---|---|
| Maximizes | Variance | Autocorrelation (Slowness) |
| Data Type | General / Static | Time-series / Sequential |
| Best For | Capturing large structural changes | Finding rare events and kinetic transitions |